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phenobarbital boosts toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may well enhance the metabolism of ifosfamide to its Lively alkylating metabolites.Observe Carefully (1)phenobarbital will lessen the level or influence of tofacitinib by affecting hepatic/intestinal enzyme CY